AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in November 2025 (see full year).

Return flights

10 Nov - 14 Nov	Copa
11 Nov - 26 Nov	Copa
24 Nov - 27 Nov	Copa
02 Nov - 05 Nov	Copa
04 Nov - 12 Nov	Avianca
10 Nov - 15 Nov	Copa
24 Nov - 28 Nov	Avianca	direct
10 Nov - 14 Nov	Avianca	direct
07 Nov - 14 Nov	Avianca	direct
07 Nov - 11 Nov	Avianca
26 Nov - 01 Dec	Avianca	direct
26 Nov - 02 Dec	Avianca

Also check the deals for one-way flights from Guayaquil to Rio Negro in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in November from $275

Return flights