AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in August 2025 (see full year).

Return flights

12 Aug - 20 Aug	Copa
01 Aug - 06 Aug	Avianca
31 Aug - 07 Sep	Avianca
25 Aug - 29 Aug	Copa
13 Aug - 27 Aug	Copa
04 Aug - 08 Aug	Avianca	direct
11 Aug - 22 Aug	Avianca	direct
13 Aug - 20 Aug	Copa
18 Aug - 22 Aug	Avianca	direct
11 Aug - 15 Aug	Avianca	direct
11 Aug - 18 Aug	Avianca
23 Aug - 07 Sep	Avianca
30 Aug - 03 Sep	Avianca
25 Aug - 01 Sep	Avianca
29 Aug - 01 Sep	Avianca
27 Aug - 01 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Guayaquil to Rio Negro in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in August from $288

Return flights