AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

20 Sep - 26 Sep	Copa
26 Sep - 30 Sep	Copa
26 Sep - 29 Sep	Avianca	direct
15 Sep - 19 Sep	Avianca	direct
07 Sep - 12 Sep	Avianca
08 Sep - 13 Sep	Avianca
08 Sep - 12 Sep	Avianca
09 Sep - 12 Sep	Avianca
26 Sep - 28 Sep	Avianca
07 Sep - 13 Sep	Avianca
29 Sep - 06 Oct	Avianca	direct
29 Sep - 03 Oct	Avianca	direct
15 Sep - 10 Oct	Avianca

Also check the deals for one-way flights from Guayaquil to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in September from $263

Return flights