AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in November 2025 (see full year).

Return flights

20 Nov - 23 Nov	Avianca
18 Nov - 22 Nov	Avianca
08 Nov - 14 Nov	Avianca
27 Nov - 30 Nov	Avianca
18 Nov - 23 Nov	Avianca
20 Nov - 22 Nov	Avianca
12 Nov - 15 Nov	Avianca
07 Nov - 01 Dec	Avianca
04 Nov - 07 Nov	Avianca
24 Nov - 28 Nov	Avianca
07 Nov - 16 Nov	Avianca
26 Nov - 02 Dec	Avianca
30 Nov - 07 Dec	Avianca
22 Nov - 22 Dec	Copa	direct
30 Nov - 07 Dec	Copa	direct
21 Nov - 21 Dec	Copa	direct
27 Nov - 02 Dec	Copa	direct
07 Nov - 01 Dec	Copa	direct
26 Nov - 02 Dec	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in November from $334

Return flights