AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in November 2025 (see full year).

Return flights

10 Nov - 13 Nov	Copa	direct
07 Nov - 15 Nov	Copa	direct
01 Nov - 05 Nov	Copa	direct
14 Nov - 17 Nov	Copa	direct
03 Nov - 07 Nov	Copa	direct
22 Nov - 29 Nov	Avianca
22 Nov - 29 Nov	Copa	direct
27 Nov - 01 Dec	Copa	direct
01 Nov - 04 Nov	Copa	direct
01 Nov - 01 Nov	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in November from $340

Return flights