AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in August 2025 (see full year).

Return flights

22 Aug - 29 Aug	Avianca
24 Aug - 29 Aug	Avianca
15 Aug - 23 Aug	Avianca
12 Aug - 18 Aug	Avianca
12 Aug - 15 Aug	Avianca
14 Aug - 19 Aug	Avianca
14 Aug - 17 Aug	Avianca
25 Aug - 31 Aug	Copa	direct
04 Aug - 07 Aug	Copa	direct
21 Aug - 26 Aug	Copa	direct
26 Aug - 02 Sep	Copa	direct
28 Aug - 29 Sep	Copa	direct
28 Aug - 01 Sep	Copa	direct
08 Aug - 13 Sep	Avianca
08 Aug - 13 Sep	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in August from $321

Return flights