AirHint found the following cheapest return flights from Guayaquil (GYE) to Panama City (PTY) in September 2025 (see full year).

Return flights

20 Sep - 27 Sep	Avianca
08 Sep - 11 Sep	Avianca
09 Sep - 11 Sep	Avianca
22 Sep - 25 Sep	Avianca
12 Sep - 19 Sep	Avianca
15 Sep - 18 Sep	Avianca
26 Sep - 29 Sep	Avianca
21 Sep - 27 Sep	Avianca
19 Sep - 25 Sep	Avianca
26 Sep - 30 Sep	Avianca
09 Sep - 10 Oct	Avianca
28 Sep - 02 Oct	Avianca
26 Sep - 02 Oct	Avianca
28 Sep - 02 Oct	Copa	direct
26 Sep - 02 Oct	Copa	direct
25 Sep - 02 Oct	Copa	direct
09 Sep - 10 Oct	Copa	direct

Also check the deals for one-way flights from Guayaquil to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Panama City in September from $334

Return flights