AirHint found the following cheapest return flights from Guayaquil (GYE) to Santiago (SCL) in October 2025 (see full year).

Return flights

09 Oct - 13 Oct	Avianca
16 Oct - 31 Oct	Avianca
20 Oct - 24 Oct	Avianca
14 Oct - 19 Oct	Avianca
02 Oct - 09 Oct	Avianca
17 Oct - 26 Oct	Avianca
20 Oct - 29 Oct	Avianca
09 Oct - 27 Oct	Avianca
19 Oct - 03 Nov	Avianca
07 Oct - 16 Oct	Avianca
15 Oct - 19 Oct	Avianca
28 Oct - 02 Nov	LATAM Airlines Group
29 Oct - 10 Nov	LATAM Airlines Group
01 Oct - 06 Nov	Avianca
12 Oct - 09 Nov	Avianca
29 Oct - 04 Nov	LATAM Airlines Group
29 Oct - 10 Nov	LATAM Airlines Group	direct
31 Oct - 02 Nov	LATAM Airlines Group
31 Oct - 05 Nov	Avianca
31 Oct - 03 Nov	Avianca

Also check the deals for one-way flights from Guayaquil to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Santiago in October from $310

Return flights