AirHint found the following cheapest return flights from Guayaquil (GYE) to Santiago (SCL) in August 2025 (see full year).

Return flights

05 Aug - 11 Aug	Avianca
21 Aug - 28 Aug	Avianca
06 Aug - 13 Aug	Avianca
20 Aug - 28 Aug	Avianca
20 Aug - 30 Sep	Avianca
05 Aug - 12 Aug	Avianca
06 Aug - 17 Aug	Avianca
11 Aug - 17 Aug	Avianca
07 Aug - 11 Aug	Avianca
08 Aug - 11 Aug	LATAM Airlines Group
27 Aug - 06 Sep	Avianca
01 Aug - 10 Aug	LATAM Airlines Group
29 Aug - 03 Sep	Avianca
20 Aug - 09 Sep	Avianca
31 Aug - 11 Sep	Avianca
30 Aug - 05 Sep	LATAM Airlines Group
29 Aug - 08 Sep	Copa
29 Aug - 03 Sep	LATAM Airlines Group	direct
22 Aug - 27 Sep	Copa

Also check the deals for one-way flights from Guayaquil to Santiago in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Santiago in August from $387

Return flights