AirHint found the following cheapest return flights from Guayaquil (GYE) to Santo Domingo (SDQ) in October 2025 (see full year).

Return flights

13 Oct - 21 Oct	Copa
06 Oct - 14 Oct	Copa
16 Oct - 19 Oct	Copa
13 Oct - 12 Nov	Copa
20 Oct - 18 Nov	Copa
03 Oct - 08 Oct	Copa
21 Oct - 28 Oct	Copa
01 Oct - 08 Oct	Copa
09 Oct - 19 Oct	Avianca
06 Oct - 06 Nov	Avianca
13 Oct - 06 Nov	Avianca
20 Oct - 26 Oct	Avianca

Also check the deals for one-way flights from Guayaquil to Santo Domingo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santo Domingo

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Cheapest return flights from Guayaquil to Santo Domingo in October from $409

Return flights