AirHint found the following cheapest return flights from Houston (HOU) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

01 Sep - 12 Sep	Avianca
03 Sep - 11 Sep	Spirit Airlines
03 Sep - 07 Sep	Spirit Airlines
18 Sep - 27 Sep	Spirit Airlines
18 Sep - 29 Sep	Spirit Airlines
19 Sep - 29 Sep	Spirit Airlines
18 Sep - 24 Sep	Spirit Airlines
19 Sep - 24 Sep	Spirit Airlines
19 Sep - 27 Sep	Spirit Airlines
03 Sep - 24 Sep	Spirit Airlines
30 Sep - 18 Oct	Spirit Airlines
29 Sep - 18 Oct	Spirit Airlines
30 Sep - 13 Oct	Spirit Airlines
29 Sep - 13 Oct	Spirit Airlines
22 Sep - 06 Oct	United	direct
23 Sep - 07 Oct	United	direct
24 Sep - 08 Oct	United	direct
25 Sep - 09 Oct	United	direct
29 Sep - 13 Oct	United	direct
30 Sep - 14 Oct	United	direct

Also check the deals for one-way flights from Houston to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Guatemala City in September from $215

Return flights