AirHint found the following cheapest return flights from Houston (HOU) to Madrid (MAD) in September 2025 (see full year).

Return flights

23 Sep - 30 Sep	United
16 Sep - 26 Sep	Air Canada
21 Sep - 30 Sep	Air Canada
29 Sep - 24 Oct	Brussels Airlines
28 Sep - 07 Oct	United
27 Sep - 08 Oct	Air Canada
27 Sep - 07 Oct	Air Canada
02 Sep - 09 Sep	United
08 Sep - 20 Sep	Spirit Airlines
18 Sep - 30 Sep	Air Canada
26 Sep - 09 Oct	Brussels Airlines
29 Sep - 06 Oct	United
10 Sep - 27 Sep	Spirit Airlines
26 Sep - 03 Oct	United
12 Sep - 28 Sep	Spirit Airlines
08 Sep - 15 Sep	United
11 Sep - 16 Sep	Air Canada
08 Sep - 04 Oct	United
19 Sep - 10 Oct	Air France
26 Sep - 05 Oct	Air Canada

Also check the deals for one-way flights from Houston to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Madrid in September from $481

Return flights