AirHint found the following cheapest return flights from Houston (HOU) to Panama City (PTY) in November 2025 (see full year).

Return flights

11 Nov - 18 Nov	Spirit Airlines
15 Nov - 22 Nov	Spirit Airlines
12 Nov - 24 Nov	Spirit Airlines
20 Nov - 26 Nov	Volaris El Salvador
19 Nov - 23 Nov	Spirit Airlines
22 Nov - 29 Nov	Volaris
11 Nov - 18 Nov	United	direct
12 Nov - 24 Nov	United	direct
15 Nov - 22 Nov	United	direct
22 Nov - 29 Nov	United	direct

Also check the deals for one-way flights from Houston to Panama City in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in November from $370

Return flights