AirHint found the following cheapest return flights from Houston (HOU) to Santiago (SCL) in December 2025 (see full year).

Return flights

11 Dec - 18 Dec	Spirit Airlines
14 Dec - 21 Dec	Spirit Airlines
15 Dec - 22 Dec	Spirit Airlines
12 Dec - 19 Dec	Spirit Airlines
17 Dec - 24 Dec	Spirit Airlines
11 Dec - 18 Dec	United	direct
15 Dec - 22 Dec	United	direct
12 Dec - 19 Dec	United	direct
14 Dec - 21 Dec	United	direct
17 Dec - 24 Dec	United	direct

Also check the deals for one-way flights from Houston to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Santiago in December from $721

Return flights