AirHint found the following cheapest return flights from Houston (IAH) to Panama City (PTY) in December 2025 (see full year).

Return flights

10 Dec - 19 Dec	Spirit Airlines
09 Dec - 16 Dec	Spirit Airlines
10 Dec - 13 Dec	Spirit Airlines
16 Dec - 13 Jan	Spirit Airlines
27 Dec - 01 Jan	Frontier Airlines
21 Dec - 27 Dec	Viva
10 Dec - 17 Dec	Delta
30 Dec - 04 Jan	Frontier Airlines
18 Dec - 02 Jan	Frontier Airlines
20 Dec - 15 Jan	Spirit Airlines
20 Dec - 15 Jan	United	direct
16 Dec - 13 Jan	United	direct
09 Dec - 16 Dec	United	direct
10 Dec - 17 Dec	United	direct
18 Dec - 02 Jan	United	direct
27 Dec - 01 Jan	United	direct
21 Dec - 27 Dec	United	direct
30 Dec - 04 Jan	United	direct
10 Dec - 19 Dec	United	direct
10 Dec - 13 Dec	United	direct

Also check the deals for one-way flights from Houston to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Panama City in December from $468

Return flights