AirHint found the following cheapest return flights from Houston (IAH) to Santiago (SCL) in November 2025 (see full year).

Return flights

09 Nov - 15 Nov	Spirit Airlines
06 Nov - 19 Nov	Spirit Airlines
19 Nov - 26 Nov	Spirit Airlines
01 Nov - 08 Nov	Spirit Airlines
19 Nov - 26 Nov	United	direct
06 Nov - 19 Nov	United	direct
21 Nov - 29 Nov	Volaris
01 Nov - 08 Nov	United	direct
09 Nov - 15 Nov	United	direct

Also check the deals for one-way flights from Houston to Santiago in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Santiago in November from $550

Return flights