AirHint found the following cheapest return flights from Indianapolis (IND) to Madrid (MAD) in October 2025 (see full year).

Return flights

07 Oct - 14 Oct	Iberia
21 Oct - 28 Oct	United
01 Oct - 08 Oct	Iberia
30 Oct - 06 Nov	Iberia
17 Oct - 24 Oct	United
08 Oct - 01 Nov	Spirit Airlines
09 Oct - 16 Oct	Iberia
09 Oct - 01 Nov	Spirit Airlines
03 Oct - 10 Oct	Iberia
23 Oct - 30 Oct	United
27 Oct - 03 Nov	Iberia
25 Oct - 01 Nov	Iberia
19 Oct - 26 Oct	Iberia
05 Oct - 12 Oct	Iberia
11 Oct - 18 Oct	Iberia

Also check the deals for one-way flights from Indianapolis to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Indianapolis to Madrid in October from $585

Return flights