AirHint found the following cheapest return flights from Indianapolis (IND) to Madrid (MAD) in September 2025 (see full year).

Return flights

21 Sep - 29 Sep	Spirit Airlines
01 Sep - 08 Sep	Spirit Airlines
17 Sep - 24 Sep	British Airways
22 Sep - 29 Sep	Iberia
02 Sep - 09 Sep	United
27 Sep - 04 Oct	Iberia
08 Sep - 15 Sep	United
14 Sep - 21 Sep	United
11 Sep - 18 Sep	United
05 Sep - 12 Sep	Iberia

Also check the deals for one-way flights from Indianapolis to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Indianapolis to Madrid in September from $541

Return flights