AirHint found the following cheapest return flights from Iquique (IQQ) to La Serena (LSC) in December 2025 (see full year).

Return flights

20 Dec - 06 Jan	JetSmart	direct
19 Dec - 06 Jan	JetSmart	direct
20 Dec - 09 Jan	JetSmart	direct
25 Dec - 06 Jan	JetSmart	direct
25 Dec - 09 Jan	JetSmart	direct
20 Dec - 21 Dec	JetSmart	direct
15 Dec - 21 Dec	JetSmart	direct
19 Dec - 21 Dec	JetSmart	direct
06 Dec - 21 Dec	JetSmart	direct
06 Dec - 08 Dec	JetSmart	direct
10 Dec - 17 Dec	Sky Airline
10 Dec - 17 Dec	Sky Airline	direct
06 Dec - 12 Dec	JetSmart	direct

Also check the deals for one-way flights from Iquique to La Serena in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Iquique to La Serena in December from $78

Return flights