AirHint found the following cheapest return flights from Istanbul (IST) to Brussels (BRU) in December 2025 (see full year).

Return flights

11 Dec - 14 Dec	AJet	direct
08 Dec - 12 Dec	AJet	direct
05 Dec - 06 Dec	AJet	direct
04 Dec - 09 Dec	AJet	direct
05 Dec - 08 Dec	AJet	direct
01 Dec - 06 Dec	AJet	direct
05 Dec - 07 Dec	AJet	direct
04 Dec - 07 Dec	AJet	direct
01 Dec - 08 Dec	AJet	direct
21 Dec - 01 Jan	AJet	direct
20 Dec - 01 Jan	AJet	direct
01 Dec - 04 Dec	Pegasus Airlines	direct
13 Dec - 04 Jan	Wizz Air Malta
29 Dec - 02 Jan	AJet	direct
25 Dec - 01 Jan	AJet	direct
30 Dec - 04 Jan	AJet	direct
28 Dec - 02 Jan	AJet	direct
30 Dec - 08 Jan	AJet	direct
30 Dec - 02 Jan	AJet	direct
28 Dec - 05 Jan	AJet	direct

Also check the deals for one-way flights from Istanbul to Brussels in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Brussels in December from $124

Return flights