AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

17 Sep - 30 Sep	KLM
16 Sep - 24 Sep	KLM
18 Sep - 28 Sep	KLM
19 Sep - 29 Sep	KLM
11 Sep - 24 Sep	KLM
03 Sep - 30 Sep	Air France
19 Sep - 30 Sep	KLM
16 Sep - 23 Sep	KLM
08 Sep - 22 Sep	KLM
09 Sep - 23 Sep	KLM
01 Sep - 20 Oct	Air Europa
01 Sep - 20 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in September from $791

Return flights