AirHint found the following cheapest return flights from Istanbul (IST) to Karachi (KHI) in September 2025 (see full year).

Return flights

02 Sep - 16 Sep	Flynas
09 Sep - 16 Sep	Flynas
20 Sep - 30 Oct	Pegasus Airlines
09 Sep - 30 Sep	Flynas
02 Sep - 02 Oct	Flynas
27 Sep - 04 Oct	Pegasus Airlines
20 Sep - 27 Sep	Pegasus Airlines
16 Sep - 27 Sep	Pegasus Airlines
02 Sep - 09 Sep	Gulf Air
10 Sep - 30 Sep	Gulf Air
03 Sep - 03 Oct	Gulf Air
19 Sep - 04 Oct	Pegasus Airlines
28 Sep - 18 Oct	Gulf Air
04 Sep - 19 Sep	Gulf Air
25 Sep - 23 Oct	Gulf Air
12 Sep - 18 Sep	Gulf Air
27 Sep - 18 Oct	Gulf Air
13 Sep - 28 Sep	Gulf Air
01 Sep - 01 Oct	Gulf Air
19 Sep - 04 Oct	Pegasus Airlines	direct

Also check the deals for one-way flights from Istanbul to Karachi in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Karachi in September from $339

Return flights