AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in October 2025 (see full year).

Return flights

02 Oct - 09 Oct	Wizz Air
09 Oct - 12 Oct	Wizz Air
16 Oct - 19 Oct	Wizz Air UK
18 Oct - 21 Oct	Wizz Air UK
03 Oct - 07 Oct	Wizz Air
01 Oct - 28 Nov	Wizz Air UK
08 Oct - 14 Oct	Pegasus Airlines
24 Oct - 29 Oct	Pegasus Airlines
14 Oct - 25 Oct	Wizz Air UK
10 Oct - 17 Oct	Wizz Air UK
06 Oct - 13 Oct	Wizz Air UK
08 Oct - 04 Nov	Wizz Air UK
22 Oct - 01 Nov	Wizz Air UK
29 Oct - 02 Nov	AJet
24 Oct - 02 Nov	Pegasus Airlines
30 Oct - 05 Nov	Wizz Air
31 Oct - 02 Nov	Fly One
31 Oct - 03 Nov	Aegean Airlines
30 Oct - 02 Nov	Wizz Air
26 Oct - 02 Nov	Aegean Airlines

Also check the deals for one-way flights from Istanbul to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Cheapest return flights from Istanbul to Madrid in October from $196

Return flights