AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in May 2026 (see full year).

Return flights

23 May - 31 May	Aegean Airlines
01 May - 10 May	Aegean Airlines
22 May - 07 Jun	Aegean Airlines
01 May - 04 May	Aegean Airlines
24 May - 30 May	Aegean Airlines
28 May - 03 Jun	Aegean Airlines
26 May - 30 May	Aegean Airlines
26 May - 30 May	Air Europa	direct
01 May - 10 May	Air Europa	direct
28 May - 03 Jun	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to Madrid in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Madrid in May from $239

Return flights