AirHint found the following cheapest return flights from Istanbul (IST) to Madrid (MAD) in September 2025 (see full year).

Return flights

11 Sep - 16 Sep	Wizz Air
10 Sep - 16 Sep	Wizz Air
22 Sep - 27 Sep	Wizz Air UK
16 Sep - 30 Sep	Wizz Air UK
11 Sep - 18 Sep	Wizz Air
10 Sep - 15 Sep	Wizz Air
23 Sep - 30 Sep	Wizz Air
23 Sep - 25 Sep	Wizz Air
12 Sep - 15 Sep	Wizz Air
16 Sep - 23 Sep	Wizz Air UK
23 Sep - 07 Oct	Wizz Air
30 Sep - 07 Oct	Wizz Air UK
27 Sep - 01 Oct	Wizz Air UK
30 Sep - 08 Oct	Pegasus Airlines
29 Sep - 13 Oct	Wizz Air UK
26 Sep - 03 Oct	Wizz Air
28 Sep - 18 Oct	Wizz Air UK
27 Sep - 01 Oct	Air Europa	direct
30 Sep - 08 Oct	Pegasus Airlines	direct
28 Sep - 18 Oct	Pegasus Airlines	direct

Also check the deals for one-way flights from Istanbul to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Madrid in September from $180

Return flights