AirHint found the following cheapest return flights from Istanbul (IST) to Milano (MXP) in December 2025 (see full year).

Return flights

17 Dec - 12 Jan	Aegean Airlines
05 Dec - 11 Dec	AJet
06 Dec - 07 Dec	Air France
05 Dec - 07 Dec	AJet
13 Dec - 14 Dec	Aegean Airlines
25 Dec - 17 Jan	Air France
17 Dec - 12 Jan	Turkish Airlines	direct
01 Dec - 08 Dec	Wizz Air
06 Dec - 11 Dec	Fly One
05 Dec - 06 Dec	SKY express
05 Dec - 09 Dec	SKY express
03 Dec - 06 Dec	SKY express
03 Dec - 09 Dec	SKY express
25 Dec - 17 Jan	Turkish Airlines	direct
27 Dec - 02 Jan	Lufthansa
27 Dec - 02 Jan	Turkish Airlines	direct
27 Dec - 13 Jan	Fly One
27 Dec - 10 Jan	Fly One
27 Dec - 17 Jan	Fly One
27 Dec - 12 Jan	Fly One

Also check the deals for one-way flights from Istanbul to Milano in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Milano in December from $142

Return flights