AirHint found the following cheapest return flights from Istanbul (IST) to San Francisco (SFO) in October 2025 (see full year).

Return flights

20 Oct - 27 Oct	KLM
20 Oct - 27 Nov	KLM
21 Oct - 28 Oct	KLM
06 Oct - 20 Oct	KLM
13 Oct - 24 Oct	KLM
08 Oct - 27 Oct	Air France
15 Oct - 15 Nov	Air France
08 Oct - 21 Oct	Air France
15 Oct - 19 Oct	Air France
15 Oct - 21 Oct	Air France
13 Oct - 22 Oct	British Airways
28 Oct - 06 Nov	British Airways
28 Oct - 28 Nov	British Airways
02 Oct - 09 Oct	Air France
17 Oct - 02 Nov	Delta
15 Oct - 01 Nov	Pegasus Airlines
16 Oct - 01 Nov	Pegasus Airlines
17 Oct - 01 Nov	LOT
28 Oct - 06 Nov	Turkish Airlines	direct
20 Oct - 27 Nov	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to San Francisco in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to San Francisco in October from $486

Return flights