AirHint found the following cheapest return flights from Istanbul (IST) to San Francisco (SFO) in November 2025 (see full year).

Return flights

08 Nov - 17 Nov	KLM
07 Nov - 10 Nov	KLM
07 Nov - 15 Nov	KLM
07 Nov - 17 Nov	KLM
20 Nov - 25 Nov	KLM
18 Nov - 28 Nov	KLM
06 Nov - 15 Nov	KLM
04 Nov - 25 Nov	KLM
10 Nov - 17 Nov	KLM
17 Nov - 27 Nov	KLM
22 Nov - 06 Dec	KLM
26 Nov - 06 Dec	KLM
27 Nov - 06 Dec	KLM
20 Nov - 11 Dec	KLM
19 Nov - 15 Dec	British Airways
26 Nov - 15 Dec	British Airways
20 Nov - 10 Dec	British Airways
06 Nov - 26 Dec	British Airways
13 Nov - 05 Dec	Lufthansa
14 Nov - 05 Dec	LOT

Also check the deals for one-way flights from Istanbul to San Francisco in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to San Francisco in November from $486

Return flights