Cheapest return flights from Istanbul to San Francisco in September from $542

AirHint found the following cheapest return flights from Istanbul (IST) to San Francisco (SFO) in September 2025 (see full year).

Return flights

24 Sep - 15 Oct KLM
24 Sep - 24 Oct KLM
25 Sep - 30 Sep British Airways
22 Sep - 28 Sep KLM
22 Sep - 29 Sep KLM
27 Sep - 04 Oct British Airways
24 Sep - 03 Oct Lufthansa
22 Sep - 04 Oct Delta
26 Sep - 02 Oct Delta
25 Sep - 02 Oct Delta
28 Sep - 13 Oct KLM
24 Sep - 15 Oct Turkish Airlines direct
24 Sep - 24 Oct Turkish Airlines direct
22 Sep - 29 Sep Turkish Airlines direct
22 Sep - 28 Sep Turkish Airlines direct
20 Sep - 20 Sep Wizz Air UK
20 Sep - 20 Sep Turkish Airlines direct

Also check the deals for one-way flights from Istanbul to San Francisco in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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