AirHint found the following cheapest return flights from New York (JFK) to Santiago (SCL) in September 2025 (see full year).

Return flights

23 Sep - 29 Sep	Frontier Airlines
26 Sep - 28 Sep	Frontier Airlines
22 Sep - 29 Sep	LATAM Airlines Group
21 Sep - 28 Sep	LATAM Airlines Group
23 Sep - 29 Sep	LATAM Airlines Group	direct
26 Sep - 28 Sep	LATAM Airlines Group	direct
21 Sep - 26 Sep	LATAM Airlines Group
22 Sep - 22 Sep	Avianca
21 Sep - 26 Sep	LATAM Airlines Group	direct
21 Sep - 28 Sep	LATAM Airlines Group	direct

Also check the deals for one-way flights from New York to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from New York to Santiago in September from $641

Return flights