AirHint found the following cheapest return flights from Santorini (Thira) (JTR) to Istanbul (IST) in October 2025 (see full year).

Return flights

11 Oct - 14 Oct	Aegean Airlines
11 Oct - 12 Oct	Aegean Airlines
24 Oct - 26 Oct	Aegean Airlines
14 Oct - 19 Oct	Ryanair
04 Oct - 11 Oct	Aegean Airlines
04 Oct - 11 Oct	Aegean Airlines	direct
19 Oct - 07 Nov	SKY express
12 Oct - 23 Oct	SKY express
12 Oct - 14 Oct	SKY express
12 Oct - 22 Oct	SKY express
12 Oct - 17 Oct	SKY express
19 Oct - 05 Nov	SKY express
26 Oct - 07 Nov	SKY express
26 Oct - 05 Nov	SKY express
26 Oct - 13 Nov	SKY express

Also check the deals for one-way flights from Santorini (Thira) to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santorini (Thira) to Istanbul in October from $215

Return flights