AirHint found the following cheapest return flights from Los Angeles (LAX) to Panama City (PTY) in October 2025 (see full year).

Return flights

06 Oct - 10 Oct	Spirit Airlines
23 Oct - 27 Oct	Spirit Airlines
15 Oct - 30 Oct	Spirit Airlines
30 Oct - 06 Nov	Spirit Airlines
31 Oct - 06 Nov	Frontier Airlines
29 Oct - 02 Nov	Spirit Airlines
15 Oct - 17 Oct	Spirit Airlines
08 Oct - 16 Oct	Spirit Airlines
03 Oct - 12 Oct	Frontier Airlines
12 Oct - 19 Oct	Avianca
10 Oct - 16 Oct	Avianca
15 Oct - 30 Oct	Copa	direct
23 Oct - 27 Oct	Copa	direct
29 Oct - 02 Nov	Copa	direct
30 Oct - 06 Nov	Copa	direct
31 Oct - 06 Nov	Copa	direct
23 Oct - 01 Nov	Avianca

Also check the deals for one-way flights from Los Angeles to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Los Angeles to Panama City in October from $446

Return flights