AirHint found the following cheapest return flights from London (LCY) to Prague (PRG) in September 2025 (see full year).

Return flights

07 Sep - 10 Sep	KLM
01 Sep - 04 Sep	KLM
18 Sep - 23 Sep	KLM
07 Sep - 11 Sep	KLM
02 Sep - 05 Sep	KLM
23 Sep - 26 Sep	KLM
22 Sep - 26 Sep	KLM
22 Sep - 25 Sep	KLM
28 Sep - 02 Oct	KLM
29 Sep - 02 Oct	KLM
30 Sep - 07 Oct	KLM
30 Sep - 03 Oct	KLM
06 Sep - 13 Sep	KLM
01 Sep - 05 Sep	KLM
30 Sep - 06 Oct	KLM
08 Sep - 03 Oct	KLM
27 Sep - 01 Oct	SWISS
27 Sep - 02 Oct	SWISS
28 Sep - 05 Oct	KLM
20 Sep - 04 Oct	KLM

Also check the deals for one-way flights from London to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Prague in September from $255

Return flights