AirHint found the following cheapest return flights from London (LCY) to Santiago (SCL) in October 2025 (see full year).

Return flights

06 Oct - 19 Oct	Delta
06 Oct - 17 Oct	KLM
27 Oct - 25 Nov	Delta
22 Oct - 15 Nov	Delta
23 Oct - 30 Oct	Delta
27 Oct - 02 Nov	Delta
21 Oct - 28 Oct	KLM
24 Oct - 08 Nov	KLM
23 Oct - 06 Nov	KLM
20 Oct - 08 Nov	KLM
07 Oct - 04 Nov	KLM
08 Oct - 05 Nov	KLM
16 Oct - 23 Oct	ITA Airways
10 Oct - 13 Oct	ITA Airways
06 Oct - 17 Nov	KLM
05 Oct - 18 Oct	KLM
03 Oct - 18 Oct	KLM
10 Oct - 17 Oct	KLM
11 Oct - 17 Oct	KLM
09 Oct - 06 Nov	KLM

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from London to Santiago in October from $1372

Return flights