AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in October 2025 (see full year).

Return flights

14 Oct - 18 Oct	easyJet
24 Oct - 08 Nov	easyJet
29 Oct - 01 Nov	easyJet
24 Oct - 08 Nov	easyJet	direct
28 Oct - 01 Nov	easyJet
24 Oct - 28 Oct	easyJet
13 Oct - 17 Oct	easyJet
13 Oct - 20 Oct	easyJet
06 Oct - 11 Oct	easyJet
24 Oct - 28 Oct	easyJet	direct
06 Oct - 13 Oct	easyJet
17 Oct - 20 Oct	easyJet
17 Oct - 21 Oct	easyJet
06 Oct - 13 Oct	easyJet	direct
23 Oct - 01 Nov	easyJet
21 Oct - 11 Nov	Vueling Airlines
22 Oct - 11 Nov	Vueling Airlines
21 Oct - 10 Nov	Vueling Airlines
21 Oct - 06 Nov	Vueling Airlines
21 Oct - 03 Nov	Vueling Airlines

Also check the deals for one-way flights from Lisbon to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Prague in October from $139

Return flights