AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	easyJet
29 Sep - 06 Oct	easyJet
17 Sep - 20 Sep	easyJet
25 Sep - 29 Sep	easyJet
09 Sep - 16 Sep	Ryanair
27 Sep - 29 Sep	easyJet
27 Sep - 03 Oct	easyJet
24 Sep - 28 Sep	easyJet
25 Sep - 28 Sep	easyJet
17 Sep - 22 Sep	easyJet
16 Sep - 23 Sep	easyJet
16 Sep - 22 Sep	Wizz Air Malta
30 Sep - 14 Oct	Vueling Airlines
30 Sep - 06 Oct	Vueling Airlines
30 Sep - 07 Oct	Vueling Airlines
17 Sep - 06 Oct	Vueling Airlines
17 Sep - 07 Oct	Vueling Airlines
30 Sep - 18 Oct	Vueling Airlines
30 Sep - 11 Oct	Vueling Airlines
24 Sep - 06 Oct	Vueling Airlines

Also check the deals for one-way flights from Lisbon to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Lisbon to Prague in September from $169

Return flights