AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in September 2025 (see full year).

Return flights

17 Sep - 22 Sep	easyJet
30 Sep - 04 Oct	easyJet
24 Sep - 27 Sep	easyJet
06 Sep - 08 Sep	easyJet
24 Sep - 01 Oct	easyJet
24 Sep - 26 Sep	easyJet
16 Sep - 22 Sep	easyJet
18 Sep - 22 Sep	easyJet
06 Sep - 10 Sep	Wizz Air Malta
03 Sep - 08 Sep	easyJet
07 Sep - 10 Sep	easyJet
08 Sep - 30 Sep	easyJet
16 Sep - 01 Oct	easyJet
23 Sep - 06 Oct	Vueling Airlines
26 Sep - 03 Oct	easyJet
23 Sep - 07 Oct	Vueling Airlines
22 Sep - 06 Oct	Vueling Airlines
24 Sep - 06 Oct	Vueling Airlines
15 Sep - 06 Oct	Vueling Airlines
23 Sep - 14 Oct	Vueling Airlines

Also check the deals for one-way flights from Lisbon to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Prague in September from $148

Return flights