AirHint found the following cheapest return flights from Lisbon (LIS) to Santiago (SCL) in October 2025 (see full year).

Return flights

29 Oct - 19 Nov	LATAM Airlines Group
29 Oct - 12 Nov	LATAM Airlines Group
29 Oct - 18 Nov	Azul Airlines
31 Oct - 09 Nov	Azul Airlines
14 Oct - 20 Nov	Ryanair
05 Oct - 28 Oct	Vueling Airlines
22 Oct - 05 Nov	LATAM Airlines Group
22 Oct - 03 Nov	LATAM Airlines Group
24 Oct - 09 Nov	Air Europa
02 Oct - 12 Oct	Ryanair
02 Oct - 14 Oct	Ryanair
24 Oct - 10 Nov	Air Europa
01 Oct - 30 Oct	Ryanair
06 Oct - 13 Oct	Ryanair
22 Oct - 01 Nov	LATAM Airlines Group
06 Oct - 21 Oct	Ryanair
06 Oct - 11 Oct	Ryanair
05 Oct - 10 Oct	Vueling Airlines
02 Oct - 05 Oct	Vueling Airlines
02 Oct - 13 Oct	Iberia

Also check the deals for one-way flights from Lisbon to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Lisbon to Santiago in October from $885

Return flights