AirHint found the following cheapest return flights from Lisbon (LIS) to Sao Tome (TMS) in September 2025 (see full year).

Return flights

26 Sep - 08 Oct	TAP
23 Sep - 10 Oct	TAP
26 Sep - 05 Oct	TAP
23 Sep - 03 Oct	TAP
26 Sep - 03 Oct	TAP
28 Sep - 12 Oct	TAP
30 Sep - 12 Oct	TAP
23 Sep - 04 Oct	TAP	direct
18 Sep - 03 Oct	TAAG Angola Airlines
12 Sep - 24 Sep	TAP
27 Sep - 04 Oct	TAP	direct
10 Sep - 24 Sep	TAP
23 Sep - 29 Sep	TAP
17 Sep - 24 Sep	TAP
06 Sep - 20 Sep	TAP	direct
12 Sep - 26 Sep	TAP
07 Sep - 24 Sep	TAP
16 Sep - 28 Sep	TAP
05 Sep - 24 Sep	TAP
23 Sep - 27 Sep	TAP	direct

Also check the deals for one-way flights from Lisbon to Sao Tome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Sao Tome in September from $710

Return flights