AirHint found the following cheapest return flights from London (LON) to Santiago (SCL) in October 2025 (see full year).

Return flights

14 Oct - 19 Oct	Ryanair
14 Oct - 15 Oct	Ryanair
13 Oct - 25 Oct	Ryanair
13 Oct - 16 Oct	Ryanair
02 Oct - 16 Oct	Vueling Airlines
02 Oct - 10 Oct	Vueling Airlines
10 Oct - 25 Oct	Ryanair
11 Oct - 28 Oct	Ryanair
11 Oct - 25 Oct	Ryanair
05 Oct - 21 Oct	Avianca
31 Oct - 09 Nov	Ryanair
30 Oct - 06 Nov	Vueling Airlines
26 Oct - 12 Nov	Avianca
22 Oct - 12 Nov	Avianca
27 Oct - 25 Nov	Ryanair
31 Oct - 16 Nov	Norse Atlantic Airways (UK)
27 Oct - 18 Nov	Ryanair
04 Oct - 03 Nov	Norse Atlantic Airways (UK)
27 Oct - 14 Nov	Ryanair
31 Oct - 10 Nov	easyJet

Also check the deals for one-way flights from London to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from London to Santiago in October from $924

Return flights