AirHint found the following cheapest return flights from Madrid (MAD) to Asuncion (ASU) in October 2025 (see full year).

Return flights

06 Oct - 31 Oct	TAP
23 Oct - 30 Oct	LATAM Airlines Group
11 Oct - 11 Nov	Avianca
23 Oct - 23 Nov	Air Europa	direct
06 Oct - 20 Oct	TAP
30 Oct - 10 Nov	Air Europa	direct
27 Oct - 02 Nov	Air Europa	direct
21 Oct - 28 Oct	Air Europa	direct
21 Oct - 04 Nov	Air Europa	direct
22 Oct - 23 Nov	Air Europa	direct
14 Oct - 04 Nov	Air Europa	direct
26 Oct - 17 Nov	Ryanair
23 Oct - 19 Nov	Air Europa	direct
27 Oct - 17 Nov	Avianca
14 Oct - 28 Oct	Ryanair
14 Oct - 21 Oct	Ryanair
06 Oct - 16 Oct	TAP
11 Oct - 21 Oct	Avianca
10 Oct - 28 Oct	Air Europa	direct
12 Oct - 28 Oct	Air Europa	direct

Also check the deals for one-way flights from Madrid to Asuncion in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Asuncion in October from $1065

Return flights