AirHint found the following cheapest return flights from Madrid (MAD) to Asuncion (ASU) in October 2025 (see full year).

Return flights

22 Oct - 05 Nov	Air Europa	direct
23 Oct - 31 Oct	Air Europa	direct
31 Oct - 17 Nov	Air Europa	direct
31 Oct - 21 Nov	Air Europa	direct
09 Oct - 31 Oct	Avianca
18 Oct - 25 Nov	Air Europa	direct
06 Oct - 27 Oct	TAP
28 Oct - 25 Nov	Iberia
09 Oct - 31 Oct	Air Europa	direct
14 Oct - 29 Oct	Azul Airlines
01 Oct - 15 Oct	Air Europa	direct
08 Oct - 11 Oct	Air Europa
01 Oct - 31 Oct	TAP
04 Oct - 19 Oct	Avianca
01 Oct - 27 Oct	TAP

Also check the deals for one-way flights from Madrid to Asuncion in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Asuncion in October from $975

Return flights