AirHint found the following cheapest return flights from Madrid (MAD) to Asuncion (ASU) in September 2025 (see full year).

Return flights

04 Sep - 05 Oct	LATAM Airlines Group
12 Sep - 28 Sep	LATAM Airlines Group
18 Sep - 18 Oct	LATAM Airlines Group
01 Sep - 28 Sep	TAP
18 Sep - 27 Sep	Azul Airlines
01 Sep - 26 Sep	Iberia
09 Sep - 01 Oct	Azul Airlines
13 Sep - 14 Oct	Azul Airlines
01 Sep - 15 Sep	TAP
27 Sep - 06 Oct	LATAM Airlines Group
01 Sep - 30 Sep	TAP
10 Sep - 21 Sep	Azul Airlines
30 Sep - 28 Oct	Avianca
13 Sep - 27 Sep	TAP
16 Sep - 22 Sep	TAP
08 Sep - 22 Sep	TAP
01 Sep - 01 Oct	Iberia
04 Sep - 05 Oct	Air Europa	direct
20 Sep - 04 Oct	LATAM Airlines Group
21 Sep - 04 Oct	Avianca

Also check the deals for one-way flights from Madrid to Asuncion in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Asuncion in September from $920

Return flights