AirHint found the following cheapest return flights from Madrid (MAD) to Cape Town (CPT) in September 2025 (see full year).

Return flights

18 Sep - 25 Sep	KLM
18 Sep - 30 Sep	KLM
24 Sep - 19 Oct	Pegasus Airlines
30 Sep - 05 Oct	Air Europa
16 Sep - 21 Sep	KLM
29 Sep - 03 Oct	Ryanair
24 Sep - 07 Oct	KLM
24 Sep - 30 Sep	KLM
28 Sep - 03 Oct	Iberia
17 Sep - 21 Sep	KLM
28 Sep - 05 Oct	Iberia
21 Sep - 29 Sep	Pegasus Airlines
29 Sep - 14 Oct	Ryanair
20 Sep - 01 Oct	KLM
14 Sep - 21 Sep	KLM
22 Sep - 01 Oct	Wizz Air
22 Sep - 27 Sep	Wizz Air
24 Sep - 01 Oct	Wizz Air Malta
16 Sep - 19 Sep	Pegasus Airlines
17 Sep - 20 Sep	KLM

Also check the deals for one-way flights from Madrid to Cape Town in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Cape Town in September from $743

Return flights