AirHint found the following cheapest return flights from Madrid (MAD) to Cape Town (CPT) in September 2025 (see full year).

Return flights

30 Sep - 20 Oct	Iberia
30 Sep - 12 Oct	Iberia
22 Sep - 13 Oct	Ethiopian Airlines
08 Sep - 14 Sep	KLM
02 Sep - 09 Sep	KLM
05 Sep - 15 Sep	KLM
21 Sep - 30 Sep	Air France
15 Sep - 29 Sep	Air France
15 Sep - 30 Sep	Air France
25 Sep - 20 Oct	Iberia
21 Sep - 12 Oct	Air France
08 Sep - 17 Sep	KLM
07 Sep - 21 Sep	KLM
08 Sep - 23 Sep	KLM
16 Sep - 23 Sep	KLM
24 Sep - 19 Oct	KLM
27 Sep - 20 Oct	TAP
29 Sep - 21 Oct	KLM
29 Sep - 20 Oct	KLM

Also check the deals for one-way flights from Madrid to Cape Town in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Cape Town

Cheap car rent in Cape Town

Cheapest return flights from Madrid to Cape Town in September from $651

Return flights