AirHint found the following cheapest return flights from Madrid (MAD) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

19 Sep - 01 Oct	United
05 Sep - 27 Sep	United
11 Sep - 23 Sep	United
10 Sep - 22 Sep	United
11 Sep - 22 Sep	United
23 Sep - 30 Sep	United
05 Sep - 20 Sep	United
15 Sep - 29 Sep	United
24 Sep - 01 Oct	United
12 Sep - 27 Sep	United
06 Sep - 26 Sep	United
07 Sep - 20 Sep	United
26 Sep - 06 Oct	United
20 Sep - 18 Oct	United
20 Sep - 20 Oct	United
20 Sep - 19 Oct	United
13 Sep - 04 Oct	United
20 Sep - 01 Oct	Brussels Airlines
27 Sep - 07 Oct	United
02 Sep - 14 Oct	Brussels Airlines

Also check the deals for one-way flights from Madrid to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guatemala City in September from $626

Return flights