AirHint found the following cheapest return flights from Madrid (MAD) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

24 Sep - 07 Oct	Ryanair
16 Sep - 30 Sep	United
17 Sep - 30 Sep	United
18 Sep - 01 Oct	United
15 Sep - 27 Sep	United
12 Sep - 22 Sep	United
14 Sep - 21 Sep	United
15 Sep - 23 Sep	United
16 Sep - 26 Sep	United
13 Sep - 26 Sep	United
12 Sep - 25 Sep	United
13 Sep - 20 Sep	United
30 Sep - 07 Oct	Brussels Airlines
14 Sep - 02 Oct	United
06 Sep - 06 Oct	United
02 Sep - 14 Oct	TAP
02 Sep - 07 Oct	Avianca
21 Sep - 14 Oct	Avianca
29 Sep - 02 Oct	WORLD2FLY
30 Sep - 02 Oct	Ryanair

Also check the deals for one-way flights from Madrid to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guatemala City in September from $645

Return flights