AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in October 2025 (see full year).

Return flights

06 Oct - 12 Oct	Avianca
04 Oct - 18 Oct	Avianca
31 Oct - 16 Nov	Avianca
24 Oct - 07 Nov	Iberia	direct
21 Oct - 03 Nov	Avianca
17 Oct - 26 Oct	Air Europa	direct
01 Oct - 17 Oct	Iberia	direct
05 Oct - 19 Oct	Iberia	direct
01 Oct - 19 Oct	Avianca
01 Oct - 12 Oct	Avianca
10 Oct - 22 Oct	Iberia	direct
31 Oct - 14 Nov	Iberia	direct
12 Oct - 03 Nov	Iberia	direct
30 Oct - 08 Nov	LATAM Airlines Group
30 Oct - 30 Nov	LATAM Airlines Group
22 Oct - 05 Nov	Air Europa	direct
24 Oct - 06 Nov	LATAM Airlines Group
27 Oct - 09 Nov	LATAM Airlines Group
09 Oct - 19 Oct	Iberia
01 Oct - 08 Oct	Avianca

Also check the deals for one-way flights from Madrid to Guayaquil in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in October from $833

Return flights