AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

01 Sep - 29 Sep	Avianca
06 Sep - 24 Sep	Avianca
05 Sep - 21 Sep	Avianca
03 Sep - 23 Sep	Avianca
03 Sep - 28 Sep	Avianca
05 Sep - 24 Sep	Avianca
20 Sep - 30 Sep	Avianca
09 Sep - 25 Sep	Avianca
09 Sep - 21 Sep	Avianca
19 Sep - 28 Sep	Avianca
26 Sep - 21 Oct	Avianca
01 Sep - 01 Oct	Avianca
03 Sep - 03 Oct	WORLD2FLY
12 Sep - 08 Oct	WORLD2FLY
12 Sep - 06 Oct	WORLD2FLY
14 Sep - 08 Oct	Iberia	direct
12 Sep - 08 Oct	Iberia	direct
16 Sep - 19 Oct	WORLD2FLY
18 Sep - 12 Oct	KLM
27 Sep - 12 Oct	Avianca

Also check the deals for one-way flights from Madrid to Guayaquil in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guayaquil in September from $818

Return flights