Cheapest return flights from Madrid to Guayaquil in September from $843

Best time to book flights for Madrid (MAD) to Guayaquil (GYE) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

17 Sep - 14 Oct Avianca
22 Sep - 30 Sep Avianca
07 Sep - 29 Sep LATAM Airlines Group
12 Sep - 24 Sep KLM
01 Sep - 14 Sep Avianca
03 Sep - 17 Sep Avianca
12 Sep - 24 Sep LATAM Airlines Group direct
25 Sep - 02 Oct LATAM Airlines Group
06 Sep - 20 Sep LATAM Airlines Group
06 Sep - 29 Sep LATAM Airlines Group
08 Sep - 11 Sep Avianca
07 Sep - 10 Sep Iberia

Also check the deals for one-way flights from Madrid to Guayaquil in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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