AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (IST) in November 2025 (see full year).

Return flights

09 Nov - 18 Nov	SKY express
20 Nov - 28 Nov	SKY express
12 Nov - 22 Nov	Air Europa
27 Nov - 14 Dec	SKY express
28 Nov - 14 Dec	SKY express
24 Nov - 14 Dec	SKY express
14 Nov - 19 Nov	SKY express
20 Nov - 26 Nov	SKY express
19 Nov - 24 Nov	Pegasus Airlines
03 Nov - 11 Nov	Aegean Airlines
05 Nov - 11 Nov	Aegean Airlines
19 Nov - 26 Nov	Pegasus Airlines
20 Nov - 24 Nov	SKY express
27 Nov - 02 Dec	SKY express
28 Nov - 02 Dec	SKY express
28 Nov - 03 Dec	SKY express
28 Nov - 01 Dec	SKY express
26 Nov - 14 Dec	SKY express
27 Nov - 03 Dec	Ryanair
28 Nov - 03 Dec	Pegasus Airlines	direct

Also check the deals for one-way flights from Madrid to Istanbul in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Istanbul in November from $144

Return flights