Cheapest return flights from Madrid to Panama City in October from $715

AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

Return flights

09 Oct - 20 Oct Iberia direct
13 Oct - 20 Oct Air Europa direct
17 Oct - 26 Oct Air Europa direct
17 Oct - 25 Oct Air Europa direct
17 Oct - 28 Oct Air Europa direct
19 Oct - 26 Oct Air Europa direct
27 Oct - 07 Nov Air Europa direct
30 Oct - 14 Nov Air Europa direct
24 Oct - 02 Nov Air Europa direct
25 Oct - 01 Nov Air Europa direct
25 Oct - 08 Nov Air Europa direct
17 Oct - 17 Nov Air Europa direct
30 Oct - 09 Nov Air Europa direct
19 Oct - 01 Nov Air Europa direct
13 Oct - 26 Oct Air Europa direct
04 Oct - 19 Oct KLM
18 Oct - 25 Oct Air Europa direct
10 Oct - 19 Oct Air Europa direct
18 Oct - 01 Nov Air Europa direct
31 Oct - 09 Nov Air Europa direct

Also check the deals for one-way flights from Madrid to Panama City in October.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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