AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in October 2025 (see full year).

Return flights

07 Oct - 26 Oct	KLM
07 Oct - 23 Oct	KLM
07 Oct - 22 Oct	KLM
07 Oct - 07 Nov	KLM
07 Oct - 25 Oct	Iberia	direct
06 Oct - 13 Oct	Air Europa	direct
06 Oct - 27 Oct	Air Europa	direct
06 Oct - 26 Oct	Air Europa	direct
07 Oct - 23 Oct	Iberia	direct
22 Oct - 15 Nov	Air Europa	direct
06 Oct - 12 Oct	Air France
06 Oct - 22 Oct	Air France
06 Oct - 07 Nov	Air France
27 Oct - 14 Nov	Air Europa	direct
23 Oct - 03 Nov	Iberia	direct
06 Oct - 07 Nov	Air Europa	direct
28 Oct - 04 Nov	Air Europa	direct
31 Oct - 24 Nov	Avianca
31 Oct - 10 Nov	United
30 Oct - 23 Nov	United

Also check the deals for one-way flights from Madrid to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in October from $706

Return flights