AirHint found the following cheapest return flights from Madrid (MAD) to Panama City (PTY) in August 2025 (see full year).

Return flights

30 Aug - 19 Sep	United
30 Aug - 13 Sep	United
28 Aug - 09 Sep	United
30 Aug - 19 Sep	Air Europa	direct
30 Aug - 13 Sep	Iberia	direct
31 Aug - 21 Sep	KLM
28 Aug - 07 Sep	United
28 Aug - 04 Sep	United
19 Aug - 19 Sep	Air France
19 Aug - 19 Sep	Air Europa	direct
21 Aug - 24 Aug	Iberia	direct
20 Aug - 27 Aug	Avianca
28 Aug - 31 Aug	Avianca
18 Aug - 25 Aug	Delta
21 Aug - 31 Aug	Delta
25 Aug - 31 Aug	Avianca
14 Aug - 24 Aug	Iberia	direct
08 Aug - 27 Aug	United
14 Aug - 27 Aug	United
12 Aug - 27 Aug	United

Also check the deals for one-way flights from Madrid to Panama City in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Panama City in August from $663

Return flights