AirHint found the following cheapest return flights from Madrid (MAD) to Quito (UIO) in October 2025 (see full year).

Return flights

08 Oct - 22 Oct	LATAM Airlines Group	direct
08 Oct - 23 Oct	LATAM Airlines Group	direct
28 Oct - 10 Nov	Delta
29 Oct - 10 Nov	Delta
30 Oct - 10 Nov	Delta
28 Oct - 11 Nov	Delta
13 Oct - 27 Oct	Ryanair
05 Oct - 12 Oct	TAP
22 Oct - 26 Oct	Iberia Express
07 Oct - 22 Oct	Iberia
22 Oct - 07 Nov	Iberia
23 Oct - 07 Nov	Iberia
24 Oct - 07 Nov	Iberia
23 Oct - 08 Nov	Avianca
28 Oct - 09 Nov	Avianca
25 Oct - 09 Nov	Avianca
10 Oct - 20 Oct	Iberia
07 Oct - 28 Oct	Iberia	direct
17 Oct - 27 Oct	Iberia	direct
07 Oct - 23 Oct	Iberia	direct

Also check the deals for one-way flights from Madrid to Quito in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Quito in October from $873

Return flights