AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in May 2026 (see full year).

Return flights

24 May - 20 Jun	Iberia	direct
01 May - 11 May	Iberia	direct
15 May - 28 May	Iberia	direct
03 May - 16 May	Iberia	direct
15 May - 30 May	Iberia	direct
03 May - 01 Jun	Iberia	direct
31 May - 13 Jun	Iberia	direct
11 May - 18 May	Avianca
08 May - 04 Jun	Iberia	direct
22 May - 23 Jun	Iberia	direct
01 May - 17 May	Avianca
01 May - 15 May	Avianca
17 May - 18 Jun	Boliviana de Aviacion	direct
15 May - 01 Jun	Boliviana de Aviacion	direct
02 May - 31 May	Air Europa
02 May - 18 May	Iberia

Also check the deals for one-way flights from Madrid to Santa Cruz in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in May from $841

Return flights