AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

01 Sep - 31 Oct	Avianca
21 Sep - 10 Oct	Avianca
12 Sep - 12 Oct	Avianca
08 Sep - 06 Oct	Avianca
17 Sep - 29 Sep	Avianca
12 Sep - 30 Sep	Avianca
19 Sep - 27 Sep	Avianca
01 Sep - 30 Sep	Avianca
17 Sep - 30 Sep	Avianca
01 Sep - 25 Sep	Avianca
16 Sep - 29 Sep	Avianca
14 Sep - 30 Sep	Avianca
15 Sep - 30 Sep	Avianca
05 Sep - 22 Sep	Air Europa	direct
05 Sep - 01 Oct	Avianca
14 Sep - 14 Oct	Air Europa	direct
02 Sep - 01 Oct	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz

Cheapest return flights from Madrid to Santa Cruz in September from $862

Return flights