AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in September 2025 (see full year).

Return flights

19 Sep - 25 Oct	Avianca
10 Sep - 22 Sep	Iberia	direct
12 Sep - 27 Sep	Iberia	direct
14 Sep - 27 Sep	Iberia	direct
07 Sep - 22 Sep	Iberia	direct
28 Sep - 04 Oct	Iberia	direct
26 Sep - 09 Oct	Iberia	direct
05 Sep - 14 Oct	Iberia	direct
05 Sep - 06 Oct	Iberia	direct
07 Sep - 28 Oct	Iberia	direct
12 Sep - 30 Oct	Iberia	direct
26 Sep - 11 Oct	Iberia	direct
15 Sep - 20 Oct	Avianca
19 Sep - 23 Oct	Avianca
01 Sep - 29 Sep	Avianca
01 Sep - 24 Sep	Avianca
07 Sep - 30 Sep	Avianca
14 Sep - 29 Sep	Avianca
10 Sep - 17 Sep	Avianca
11 Sep - 25 Sep	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz

Cheapest return flights from Madrid to Santa Cruz in September from $816

Return flights